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Bacterial Biosensor Lab
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Bacterial Biosensor Lab
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Pre-Prints:

Brasino, M.; Wagnell, E.; Manalo, E. C.; Drennan, S.; Fischer, J. M.; Merritt, J. Engineered Lactiplantibacillus Plantarum as a Biosensor Probe for the Lungs. bioRxiv September 27, 2023, p 2023.09.27.559779. https://doi.org/10.1101/2023.09.27.559779. 


Peer-reviewed Publications:

  1. Brasino, M.; Wagnell, E.; Ozdemir, E. S.; Ranganathan, S.; Merritt, J. Mutation of the Peptide-Regulated Transcription Factor ComR for Amidated Peptide Specificity and Heterologous Function in Lactiplantibacillus Plantarum WCFS1. Microbiology Spectrum 2024, 12 (6), e00517-24. https://doi.org/10.1128/spectrum.00517-24.

  2. Hamilton, S.; Shea, D.; Ibsen, S.; Brasino, M. On-Chip Dielectrophoretic Recovery and Detection of a Lactate Sensing Probiotic from Model Human Saliva. ELECTROPHORESIS 2023, 44 (3–4), 442–449. https://doi.org/10.1002/elps.202200214. 

  3. Brasino, M.; Wagnell, E.; Hamilton, S.; Ranganathan, S.; Gomes, M. M.; Branchaud, B.; Messmer, B.; Ibsen, S. D. Turning Antibodies off and on Again Using a Covalently Tethered Blocking Peptide. Commun Biol 2022, 5 (1), 1–9. https://doi.org/10.1038/s42003-022-04094-1. 

  4. Roy, S.; Brasino, M.; Beirne, J. M.; Harguindey, A.; Chapnick, D. A.; Liu, X.; Cha, J. N.; Goodwin, A. P. Enzymes Photo-Cross-Linked to Live Cell Receptors Retain Activity and EGFR Inhibition after Both Internal-ization and Recycling. Bioconjugate Chem. 2020, 31 (1), 104–112. https://doi.org/10.1021/acs.bioconjchem.9b00781.

  5. Brasino, M.; Roy, S.; Erbse, A. H.; He, L.; Mao, C.; Park, W.; Cha, J. N.; Goodwin, A. P. Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photocon-jugation and Increased Retention in Tumors. J. Am. Chem. Soc. 2018, 140 (37), 11820–11828. https://doi.org/10.1021/jacs.8b07601.

  6. He, L.; Mao, C.; Brasino, M.; Harguindey, A.; Park, W.; Goodwin, A. P.; Cha, J. N. TiO2-Capped Gold Nanorods for Plasmon-Enhanced Production of Reactive Oxygen Species and Photothermal Delivery of Chemotherapeutic Agents. ACS Appl. Mater. Interfaces 2018, 10 (33), 27965–27971. https://doi.org/10.1021/acsami.8b08868.

  7. He, L.; Brasino, M.; Mao, C.; Cho, S.; Park, W.; Goodwin, A. P.; Cha, J. N. DNA-Assembled Core-Satellite Upconverting-Metal–Organic Framework Nanoparticle Superstructures for Efficient Photodynamic Therapy. Small 2017, 13 (24), 1700504. https://doi.org/10.1002/smll.201700504.

  8. Brasino, M.; Cha, J. N. Real-Time Femtomolar Detection of Cancer Biomarkers from Photoconjugated Anti-body-Phage Constructs. Analyst 2016. https://doi.org/10.1039/c6an01904h.

  9. Brasino, M. D.; Cha, J. N. Isothermal Rolling Circle Amplification of Virus Genomes for Rapid Antigen Detection and Typing. Analyst 2015, 140 (15), 5138–5144. https://doi.org/10.1039/C5AN00721F.

  10. Brasino, M.; Lee, J. H.; Cha, J. N. Creating Highly Amplified Enzyme-Linked Immunosorbent Assay Signals from Genetically Engineered Bacteriophage. Analytical Biochemistry 2015, 470, 7–13. https://doi.org/10.1016/j.ab.2014.10.006.

  11. Hendrix, J.; Read, T.; Lalonde, J.-F.; Jensen, P. K.; Heymann, W.; Lovelace, E.; Zimmermann, S. A.; Brasino, M.; Rokicki, J.; Dowell, R. D. Engineered Calcium-Precipitable Restriction Enzyme. ACS Synth. Biol. 2014, 3 (12), 969–971. https://doi.org/10.1021/sb500042m.

  12. Vasko, S. E.; Kapetanović, A.; Talla, V.; Brasino, M. D.; Zhu, Z.; Scholl, A.; Torrey, J. D.; Rolandi, M. Se-rial and Parallel Si, Ge, and SiGe Direct-Write with Scanning Probes and Conducting Stamps. Nano Lett. 2011, 11 (6), 2386–2389. https://doi.org/10.1021/nl200742x.



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